Inhibiting USP13 Enzyme Can Help Destroy Toxic Alpha-Synuclein Clumps, Mouse Study Finds

Inhibiting an enzyme called USP13 may represent an attractive therapeutic target for Parkinson’s and other neurodegenerative diseases, preclinical data suggests. These findings also could hold important implications for a therapy currently being developed to treat Parkinson’s disease — nilotinib. The study, “Ubiquitin specific protease-13 independently regulates parkin…

2 Enzymes Seen to Degrade Clumps of Stress Granules, Raising Possibility of Using Them to Treat Parkinson’s

Understanding how two proteins, both enzymes, work to disassemble “stress granules” — clumps of molecules that form when cells are stressed by external factors — may help in developing treatments for Parkinson’s and other neurodegenerative disorders by creating enzymes that mimic their work, researchers report. The study, “Deubiquitylases…