CRISPR/Cas9 Used to Bring LRRK2 Mutation to Possible Monkey Disease Model

Using CRISPR/Cas9 gene editing tools, researchers introduced a common Parkinson’s disease mutation into stems cells of  the marmoset monkey for a first time, paving the way toward a primate model of this disease. They also showed that this common leucine-rich repeat kinase 2 (LRRK2) gene mutation behaves the same in…

Parkinson’s Monkey Model May Help Scientists Explore Non-Motor Symptoms, Study Reports

A well-known monkey model for Parkinson’s disease — used mainly for its ability to mimic human motor symptoms — can also reflect the disease’s non-motor symptoms, including sleep disturbances, changes in the body’s natural clock, and cognitive impairment, a study shows. These results highlight the usefulness of…