Computer Model May Help in Better Tailoring Levodopa Dose to Patient’s Needs

A computational model of how Parkinson’s disease evolves over time may help guide physicians in tailoring levodopa doses to a patient’s needs at given disease stages. Levodopa works to ease the slowness or difficulty in moving, known as bradykinesia, experienced by many people with Parkinson’s. But its effectiveness…

Mouse-brain Computer Model Tracks Spread of Alpha-synuclein in Parkinson’s

Researchers have developed a computer model of the mouse brain that integrates both Parkinson’s disease-related genetic risk factors and the animals’ brain networks to help them understand how abnormal alpha-synuclein protein spreads and how neurodegeneration progresses. The study, “Spread of α-synuclein pathology through the brain connectome is modulated by…

NoTremor Developed for Parkinson’s Disease Computer Simulation, Analysis, Treatment

NoTremor, a Parkinson’s disease research project funded by the European Union, is working on developing patient specific computational models of the brain and neuromuscular systems that can be used to improve the quality of Parkinsons disease (PD) analysis and progression monitoring. In particular, the NoTremor team of researchers aims…