Dysfunction Of Lysosome Protein TMEM175 Could Be Risk Factor

A protein called TMEM175 is critically important for maintaining the proper acidity of lysosomes — cellular compartments that clear waste — and its deficiency led to the buildup of the toxic protein alpha-synuclein in the brains of mice. That finding from a recent study may underlie the previously identified link…

Biogen and Alectos Team Up to Advance AL01811 for Parkinson’s

Biogen and Alectos Therapeutics have signed an exclusive license and collaboration agreement to further develop and commercialize AL01811, a small molecule therapy, as a potential treatment for Parkinson’s disease. “Through this collaboration with Alectos, we hope to improve the lives of people living with Parkinson’s disease by advancing…

Way of Supporting Lysosomes Seen to Protect Nerve Cells in Early Study

Injecting acidic nanoparticles into mice in a model of Parkinson’s disease protected against nerve cell loss and restored the ability of lysosomes, cell compartments responsible for breaking down excess or damaged proteins, to work as they should, a research team reported. “Our results support lysosomal re-acidification as a disease-modifying strategy for…