Russ Hudson
Forum Replies Created
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Try Butyric acid supplements for your constipation.
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I’ve been taking Butyric Acid supplements since September 2018, and all of my Parkinson’s symptoms have been alleviated.
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I would tell him to research Butyric acid supplements. I started taking them in September 2018, and it cured my Parkinson’s.
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After reading this, I started taking Butyric acid supplements. I highly recommend it.
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I had all of your symptoms, including the left thumb tremor. They are all gone now, after taking butyric acid supplements. I highly recommend it.
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Panic and anxiety was what I was starting to experience in September 2018, after noticing other symptoms before, such as acting out my dreams, left thumb twitching, stiffness in my left left, trouble writing, balance issues. I googled for the “latest treatments for Parkinson’s,” and found articles indicating butyric acid supplements are very helpful. I started taking them, and all of my symptoms, including panic and anxiety, have gone away.
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Daniel, I don’t take any other PD medicines.
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“I have a question about the Butyric Acid and Niacin: do you take it every day longterm, by that I mean for the rest of your life.”
I would say yes, I’ll take it for the rest of my life. I’m sure the side effects of not taking it, the return of Parkinson’s, would be worse.
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“How soon did the tremors slow or go away?”
Within a month or two
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I had all the symptoms of Parkinson’s; acting out dreams while sleeping, left thumb twitch, difficulty writing, left leg stiffness, brain fog, unsure gait, balance problems, soft speaking voice. I went on Google and entered the following search, “latest treatment for Parkinson’s.” One of the pages I found is shown below.
Bottom line? Butyric Acid supplements not only cured my Parkinson’s but reversed it’s progress.
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I recommend niacin and butyric acid supplements.
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I buy Butyrex® by T.E.Neesby online. It says the serving size is six capsules. I immediately started feeling better when I started in Sep 2018.
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Butyrate is a short-chain fatty acid (SCFA). Fatty acids are the building blocks of fats that our cells need to function. Butyrate is made when the bacteria living in our guts ferment otherwise indigestible fibers from grains, beans, onions, bananas, and other foods rich in complex carbs.
Butyrate is the preferred energy source for the cells in your colon wall. It is essential for maintaining a healthy barrier between the colon and bloodstream and it prevents inflammation in the gut.
Proponents:
•Is a major energy source for colon cells
•Believed to help prevent colon cancer
•Increases mitochondrial activity
•Prevents toxins from crossing the gut barrier
•Improves insulin sensitivity
•Promotes healthy weight
•Fight inflammation
•Prevents the growth of pathogenic bacteria
•Protects the brainSkeptics:
•Strong odor
•Lack of high-quality human research
•Difficult to separate butyrate from other short-chain fatty acids1) Gut Health
Butyrate is essential for maintaining a healthy environment in the gut. In the human colon, anaerobic bacteria such as Clostridium butyricum, Roseburia intestinalis, and Faecalibacterium prausnitzii ferment carbohydrates and produce short-chain fatty acids (SCFAs): acetate, propionate, and butyrate [3, 10, 11].
Colon Cell Energy Source
Butyrate nourishes the colon wall, maintains a healthy lining and barrier function of the colon, and prevents intestinal inflammation [4].
In the mitochondria of colon cells, 70-90% of butyrate is oxidized into acetyl-CoA, which is then used to generate large quantities of ATP, the primary form of cellular energy [12].
If you don’t have enough butyrate-producing bacteria in your gut, you may be more likely to develop diarrhea, inflammatory bowel disease (IBD), and even colon cancer [13, 14, 15, 16, 17].
Inflammatory Bowel Disease
Short-chain fatty acids, especially butyrate, can reduce the symptoms of inflammatory bowel disease (IBD). In one study of 13 people with Crohn’s disease, a type of IBD, butyrate supplements improved 69% of cases, with symptoms completely disappearing in 54% (seven participants) [18, 19, 20, 21].
There are a variety of approaches for using butyrate to manage IBD and colitis. The treatment strategies range from a high-fiber diet to butyrate-producing probiotics, coated butyrate tablets, and rectal enemas [22, 23].
Diarrhea & Gut Inflammation
Resistant starch is a type of soluble fiber that your gut bacteria can ferment into butyrate. A diet containing lots of resistant starch improved diarrhea in a trial of 57 baby boys [24].
Butyrate can also prevent inflammation and stomach ulcers caused by alcohol. Mice given butyrate before alcohol had less inflammation and damage to the lining of their stomachs [25].
Sodium butyrate in combination with other SCFAs and silicon dioxide was also shown to benefit traveler’s diarrhea, a condition common among those who travel to exotic countries [26].
According to a great many studies, butyrate is vital for healthy gut flora, controlling inflammation, and maintaining a strong intestinal barrier.
2) Inflammation
Butyrate suppresses the activity of cells and proteins that drive inflammation [27].
In one study on human cells, butyrate drastically reduced the activity of interleukin-12 (IL-12), an inflammatory cytokine, while increasing interleukin-10 (IL-10), which is generally anti-inflammatory [28].
In mice, butyrate-producing dietary fibers counteracted inflammation and illness caused by bacterial toxins. The inflammatory cytokines inhibited by butyrate included interleukin-1 (IL-1), tumor necrosis factor-alpha (TNF-alpha), and interferon gamma (INF-y) [29].
Immune Response
Butyrate may reduce inflammation by increasing the activity of immune cells called regulatory T cells or Tregs. These specialized cells stop other immune cells – Th1, Th2, and Th17 – in their tracks, before they lose control. In turn, Tregs prevent the lining of the gut from overreacting to harmless food proteins [30].
Gut Barrier
Butyrate also strengthens the barrier formed by cells in the colon wall, thus preventing microbes and bacterial toxins from invading the bloodstream [31].
Inflammation Due to Aging
As we grow older, inflammation increases throughout our bodies. In aging mice, a diet high in fiber that produces butyrate counteracted age-related increases in inflammation, suggesting that butyrate may be especially helpful to the elderly. Human studies will be required to confirm this benefit, however [32].
Animal and cell studies show that butyrate inhibits inflammatory cytokines and prevents inflammatory bacterial toxins from entering the bloodstream.
3) Fine-Tuning the Immune System
As an HDAC inhibitor, butyrate adjusts the immune system in a number of ways.
HDAC inhibitors improve the tumor-targeting abilities of immune cells like T cells and natural killer cells; they are currently under investigation as potential cancer drugs. This class of compounds also reduces many inflammatory signals and increases Tregs, a type of white blood cell that prevents allergies and autoimmunity [33, 34, 35].
Butyrate more specifically protects the gut barrier and prevents pathogens and other harmful agents from crossing into the bloodstream [36].
4) Brain and Nerve Cells
The gut and the microbiome strongly affect the brain. Your gut bacteria “talk” to your cells by releasing butyrate, which (as an HDAC inhibitor) turns on certain genes [37].
Cognition
Butyrate may improve learning and long-term memory. Similar to exercise, sodium butyrate increased brain-derived neurotrophic factor (BDNF) in mice. Simply put, butyrate supplies “brain food” (neuro = brain, trophic = food) to the hippocampus, the brain’s hub for memory and emotions. This gives birth to new neurons, called neurogenesis, a process that can reshape the brain [38].
The effect of butyrate supplements or intestinal butyrate concentration on cognition has not been tested in humans. However, this effect has been repeated multiple times in animals, and probiotics containing butyrate-producing bacteria have been associated with reduced stress in humans. Human trials on butyrate and cognition are likely to be next [39, 40, 32, 41].
Brain Injury
There’s a huge overlap between cognitive enhancement and recovery from brain damage. Both rely on neurogenesis, a process that replenishes and reshapes the brain.
In a mouse study, sodium butyrate given after a stroke supported the development of new nerve cells in the damaged areas. It also strengthened the blood-brain barrier in mice with brain trauma, which helped them recover. Butyrate-producing bacteria also strengthened this barrier in mice [42, 43, 44].
Clostridium butyricum, a butyrate-producing species of bacteria, may help manage vascular dementia, a disease whereby blood vessel blockages prevent brain cells from getting enough oxygen. In a mouse study, animals with C. butyricum in the gut experienced less cell death in their brains [45].
These effects have not yet been investigated in human trials.
Nerve Damage
Butyrate may also help manage other types of nerve damage. In guinea pigs, sodium butyrate protected nerve cells in the ear after treatment with antibiotics, thus preventing hearing loss [46].
Mice with brain damage due to lack of oxygen fared better when they were given the butyrate-producing bacteria Clostridium butyricum before the injury [47].
Sodium butyrate also prevented the death of nerve cells in the spine of mice with spinal muscular atrophy [48].
Animal studies show that butyrate is neuroprotective and may improve memory and reduce the impact of brain trauma. Human trials will be needed to confirm these effects.
Food Sources
You get can butyrate from food. For example, butyric acid abounds dairy products, especially butter. Butter, which gave butyrate its name, contains about 3 to 4% of butyrate in the form of tributyrin. Plant oils also contain butyrate to some extent [115, 116, 117].
Eating more fiber increases butyrate production by some bacteria in your gut. There is generally an association between a higher intake of plant foods and increased levels of short-chain fatty acids (SCFAs), including butyrate, in stools. However, not all plant-based foods yield butyrate; for example, diets rich in fruit or starch are associated with high butyrate levels in the gut, but starch-free wheat bran is not [118, 119, 120, 121].
Depending on the composition of your gut flora, the following fibers may encourage them to produce SFCAs, including butyrate [122, 123, 124]:
•Inulin: artichokes, garlic, leeks, onions, and asparagus
•Fructooligosaccharides (FOS): fruits and vegetables, including bananas, onions, garlic, and asparagus
•Resistant starch: cooked and cooled rice, potatoes and green bananas
•Pectin: apples, apricots, carrots, oranges, and others
•Oat bran
•Arabinoxylan
•Guar gum
•Arabinogalactan
•Hi-Maize, potato or plantain starch flours -
Phillipe, the label on the container says serving size = six capsules, which I take twice a day.
Rob, nope I’ve never tested to see why I’m not producing butyrate. It’s most likely something which, in some people, declines with age.
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Flush free Niacin, 500 mg, one pill a day.
Calcium/Magnesium Butyrex Complex, Calcium 480 mg, Magnesium 240 mg, Butyric Acid 3.6 g. Serving size six capsules, taken twice a day. -
I take niacin and butyric acid supplements. It has reversed my Parkinson’s. No more tremors, anxiety, movement dreams, difficulty writing, feeling hot, brain fog.
I take 12 pills a day of butyric acid supplements, six in the morning and six at night.
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Butyric acid supplements, have her try them. They worked for me in reversing my PD. Anxiety is also gone.
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David, I immediately felt improvement, and a bounce in my step. That said, I would estimate at least a year for my brain to heal, and it’s still getting better. Two years ago, in Feb 2018, on my annual ski trip, before I started butyric acid supplements, I frequently had to stop to catch my breath and my skis didn’t parallel properly. Last year, after six months of butyric acid supplements, I skied better but still had to stop frequently to catch my breath. This year, I skied much better and didn’t have to stop all the time to catch my breath.
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From what I’ve learned, it’s from general inflammation of the brain. The cause, I believe, is the large intestine. There’s studies out there which show the connection between the large intestine and brain health.
I started taking butyric acid supplements, which are food for the large intestine, and my PD symptoms have almost completely disappeared. Here’s a link to an article.
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I recommend you try Butyric acid supplements. They have reversed my Parkinson’s to the point where I’m essentially cured. I take six pills twice a day, and on niacin supplement.
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Andrew L.
1) Did you do this treatment on your own, or are you working in conjunction with a doc (if with a doc, is it a neurologist or internist?) I’ve gone to two PD docs, seeking a prescription for phenylbutyrate ( https://www.emcell.com/en/list_of_diseases/parkinson_treatment/news-and-articles-about/1659.htm). They wouldn’t prescribe it and pretty much blew me off.
2) How did you decide on your butyric acid dose? I found this on Google (https://selfhacked.com/blog/butyrate-health-benefits/) Joe Cohen said he took 4 pills twice a day, which I started out with.
3) Which brand do you use? I started with the brand referred to on this site (https://www.foundationalmedicinereview.com/blog/the-potential-of-butyric-acid-as-an-alternative-treatment-for-parkinsons-disease/) but then I found it cheaper elsewhere.
4) Do you take dietary fiber and any other prebiotics or probiotics as well? Nope. -
I’ve posted this before. I self-diagnosed myself in September 2018 (I had 7 out of 10 of the symptoms). I then Googled for the latest treatments for Parkinson’s, and found articles which told of the benefits of Butyric Acid supplements. I take 12 pills a day, six in the morning and six at night. Not only has my PD been stopped, but it’s been reversed as my brain has healed.
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I don’t take any PD medicines at all. In September 2018, I decided to Google PD symptoms, as my left thumb kept twitching and I had other symptoms. I found I had most of the symptoms. I then decided to Google, “latest treatments for PD,” and that’s when I found this article. https://www.foundationalmedicinereview.com/blog/the-potential-of-butyric-acid-as-an-alternative-treatment-for-parkinsons-disease/
I buy butyric acid pills on line from jigsaw health (Butyrex® by T.E.Neesby). I take six pills in the morning and six in the evening. All my PD symptoms have abated, including the tremor in my left thumb.
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My PD symptoms have been cured. How? Butyric Acid supplements. I take 12 pills a day, and I feel great. I highly recommend it ….