Genetic mutations associated with Parkinson’s disease appear to alter the processes of neuronal death, University College London (UCL) researchers suggest in a study titled “The Parkinson’s disease-linked proteins Fbxo7 and Parkin interact to mediate mitophagy,” published in Nature Neuroscience. Neurons are dependent on the integrity of mitochondria, the energy…
Researchers at the Johns Hopkins Bloomberg School of Public Health have developed “mini-brains” that may present a more accurate and effective way of testing new drugs for many neurological disorders, such as Parkinson’s disease. These human cell-derived structures, which represent an existing new alternative to animal testing, were recently discussed in…
Boise State University researchers developed a novel mouse model to assess dopaminergic (DA) neurogenesis in the substantia nigra of adult animals, and suggest that neuron regrowth is possible in adult mammals. Importantly, these neurons’ growth rate indicates that inflammatory responses may inhibit natural neuronal generation, a process that can eventually lead to Parkinson’s disease.
European Union researchers, as a part of the EU-funded BIOMARKERS FOR PD project, have developed a Parkinson’s Disease (PD) biochemical biomarker assay that could lead to early diagnosis of the disease, the development of effective treatments and the successful assessment of pathogenesis and overall physiology of the disease. Aside from the…
Brain cells in Parkinson’s disease patients can learn to respond to placebo drugs, although the training appears to wear off after 24 hours. This finding, researchers said in “Teaching neurons to respond to placebos,” a study published in The Journal of Physiology, shows it may be possible to lower Parkinson’s medication…
Alegeus recently announced it will donate a total of $20,000 to three charities chosen by employees as part of its 2015 holiday giving program. Instead of spending on corporate gifts and holiday cards, Alegeus decided to allow workers to showcase a charity of their preference via a page on the corporate…
An animal model capable of reproducing the formation of α-synuclein fibrils and, consequently, Lewy bodies — the major pathological hallmark of Parkinson’s disease — has finally been developed. Researchers reporting this achievement, in a study titled “Induction of de novo α-synuclein fibrillization in a novel neuronal model for Parkinson’s disease” and…
University of Cambridge researchers have developed the first biologically realistic model of the brain’s neuronal behavior when complex decisions are being made, and when adapting to mistakes. The mathematical model of neural decision-making activity and behavior could help researchers better understand a range of neuronal conditions, including Parkinson’s disease. The paper, “Goal-Directed…
People with Parkinson’s disease have a higher risk of bad falls and hip fractures as early as 26 years before diagnosis, partly because of a poorer sense of balance that might be an early sign of the illness, according to a study published in the journal PLOS Medicine and titled “Risk of Injurious…
Mayo Clinic researchers in Arizona and Banner Sun Health Research Institute have found that a biopsy of a portion of a person’s submandibular gland may be a feasible approach to diagnose early Parkinson’s disease. The research is published in the journal Movement Disorders and titled “Peripheral…
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