A study reports that the proteins NAP1 and SINTBAD play a role in regulating mitophagy, a process wherein damaged mitochondria are removed from cells, which is essential for helping them stay healthy. Mitophagy is impaired in Parkinson’s disease. “Targeting these proteins in [nerve cells] could be a potential avenue…
Note: This article was updated Aug. 9, 2024, to correct that the improvement seen in good on time in additional analyses was 1.5 hours per dose. The U.S. Food and Drug Administration (FDA) has approved IPX203, a novel extended-release formulation of levodopa and carbidopa, for Parkinson’s disease.
A new visual diagnostic technique called Cap-QuIC has the potential to advance the early detection of neurodegenerative diseases, such as Parkinson’s disease. “The simplicity and efficiency of Cap-QuIC could lower the barriers to routine screening for neurodegenerative diseases, ultimately leading to earlier intervention and better patient outcomes,” Hye Yoon…
Researchers have developed a new mouse model that affects nerve cells in the eye that could help in studying disease mechanisms and treatment approaches in Parkinson’s disease. The mice are lacking the protein VPS35 in specific cells of the eye and developed protein deposits that contain alpha-synuclein, neurodegeneration, and…
Compounds called polyphenols in the Ecklonia cava seaweed eased motor and nonmotor symptoms in a mouse model of Parkinson’s disease, a study reports. Treatment with the polyphenols, which are natural antioxidants and anti-inflammatory agents, also prevented the loss of dopamine-producing neurons, a hallmark of Parkinson’s disease. The benefits are…
From Monterey Bay in California to Hanalei Bay in Kauai, Hawaii, Team HPP (Human Powered Potential) has rowed 2,800 miles across the Pacific Ocean and raised $28 million to benefit The Michael J. Fox Foundation for Parkinson’s Research (MJFF) and its efforts to better treat and cure Parkinson’s disease.
Boosting levels of the Cdk8 gene in fruit flies with Parkinson’s-like symptoms improved their ability to move, possibly due in part to preserving the health of mitochondria, the energy-producing structures within cells, a recent study reports. While it’s still early to know if this gene’s human counterparts, CDK8 and CDK19, also…
A person’s body composition, like the ratio of fat to muscle mass, could influence their risk of neurodegenerative diseases such as Parkinson’s and Alzheimer’s, according to a large database study in the U.K. Among the more than 400,000 middle-aged adults followed for years, higher levels of abdominal and…
Nearly 13% of people with Parkinson’s disease in North America carry a Parkinson’s-associated genetic mutation, according to new data from the PD GENEration study. This suggests that genetic variants with a link to Parkinson’s are more common than previously thought. “The positivity rate and the high interest in…
Scientists at the University of Florida (UF) have developed an artificial intelligence-powered tool to help neurologists track Parkinson’s disease progression. The system analyzes video of patients’ performance on the finger-tapping test, a standard test that requires the patient to quickly tap the thumb and index finger about 10 times. It…
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