A University of Alberta pharmacology professor and researcher will use a CA $1.04 million grant to investigate the potential role of fatty molecules — called gangliosides — in treating neurodegenerative diseases, including Parkinson’s disease. The grant, from the Canadian Institutes of Health Research (CIHR) and worth about $826,000, was…
A grant from the Michael J. Fox Foundation (MJFF) will help Clene Nanomedicine to advance in development CNM-Au8, its cellular energy-promoting, investigational Parkinson’s treatment. The grant will help to support preclinical studies in patients’ nerve cells and mouse models of the disease, as well as facilitate the launch of a Phase 2 safety and effectiveness…
Changes in the composition of fat molecules on the membranes of nerve cells appear to change how the alpha-synuclein protein interacts with these same cell membranes, possibly promoting the aggregation that characterizes Parkinson’s disease, new research reports. The study, “The docking of synaptic vesicles on the presynaptic membrane induced by…
Abnormal blood sugar (glucose) levels, either lower or higher than the norm, appears to be linked with a faster progression of motor difficulties in people with Parkinson’s disease, research suggests. The brief report on this finding, “Euglycemia Indicates Favorable Motor Outcome in Parkinson’s Disease,” was published in the journal…
Parkinson’s UK is paving the way for a future clinical trial that will continue to test a naturally occurring protein, the glial cell line-derived neurotrophic factor or GDNF, as a potential therapy for slowing Parkinson’s disease progression. The new trial will follow a 2019 clinical study of…
Blackfynn announced that its is acquiring the rights to a candidate Parkinson’s disease treatment that others gave up on but is thought ready to move into pivotal Phase 3 testing. Neither the investigative treatment nor the company that initially developed it — or other details of this acquisition — were…
Q-State Biosciences has developed a set of optimized antisense oligonucleotides (ASOs) that may serve as potential therapies for Parkinson’s disease patients with specific mutations, the company announced. These ASO candidates are designed for patients carrying mutations in the GBA gene, a key genetic risk factor for the disease’s development. Their…
A scientist at the University of Latvia claimed a journal’s Young Investigator Award for her research showing how small vesicles derived from stem cells could lessen motor symptoms in a rat model of Parkinson’s disease. Karīna Narbute’s work establishes a proof of concept for the potential of small vesicles —…
Vercise Genus, a fourth-generation system for deep brain stimulation (DBS) to treat people with Parkinson’s disease, is now available in the U.S., Boston Scientific, which markets the system, announced. The U.S. Food and Drug Administration approved the system’s conditional use with full-body MRI scans, following a similar…
Teva has discontinued Spiroco (ropinirole) 4mg XL prolonged-release tablets due to factors out of the company’s control, according to an announcement from Parkinson’s UK. The company — which outside the U.S. manufactures ropinirole XL as a generic formulation in three concentrations — is still marketing Spiroco…
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