A newly developed test was able to distinguish — with an accuracy of 95% — between individuals with and without Parkinson’s disease, using samples of cerebrospinal fluid (CSF), the liquid surrounding the brain and spinal cord, according to a new study from Germany. The researchers noted that Parkinson’s often…

A new artificial intelligence (AI) tool may help predict the structure of amyloid fibrils, that is, misfolded protein fibers that accumulate in the brain of people with neurodegenerative diseases such as Parkinson’s. Called Ribbonfold, the tool is designed to address the complex and variable structures of misfolded proteins by…

Nearly 1 in 8 people diagnosed with Parkinson’s disease in Finland within the past couple of decades were later given a different diagnosis, usually within two years, underscoring the need for better clinical criteria and regular checkups. When Parkinson’s and dementia with Lewy bodies, a neurodegenerative disease also…

Nitrase Therapeutics’ NDC-0524, an antibody therapy for Parkinson’s disease, significantly reduced alpha-synuclein aggregation and spreading in mouse models of the disease, according to preclinical data released by the company. The antibody targets nitrated alpha-synuclein, a misfolded form of the protein that forms toxic clumps in dopaminergic neurons, the nerve cells…

A new collaborative effort between Mayo Clinical Laboratories and Amprion will expand access to the diagnostic company’s SAAmplify–αSYN test — designed to detect the presence of abnormal alpha-synuclein protein in people suspected of having neurodegenerative diseases — across the U.S., according to a joint press release.

NDC-0524, an experimental antibody that Nitrase Therapeutics is developing as a treatment for people with Parkinson’s disease, is expected to enter clinical testing in the fourth quarter of 2025, or before the end of the year, according to a company press release. The antibody, which targets nitrated…

Neurons, or nerve cells, that release a signaling molecule called glutamate within the enteric nervous system — a network of nerve cells embedded in the gut wall — play a crucial role in regulating bowel movements, according to a Stanford University study that ultimately could lead to new ways to…

Among people with rapid eye movement (REM) sleep behavior disorder, blood biomarkers associated with dementia may help identify those at risk of developing Dementia with Lewy Bodies (DLB), a condition that shares symptoms with Parkinson’s disease. Particularly, blood levels of two proteins — amyloid-beta 42/40 ratio and p-tau…

People with dementia related to Parkinson’s disease are at increased risk of death after undergoing surgery to address broken hips, a new study reports. Data suggest this increased risk is higher in people with Parkinson’s-related dementia than other types of dementia. “Our analysis of dementia subtypes reveals that not…

A compound formed by nerve cells as they break down cholesterol appears to be involved in the formation of toxic alpha-synuclein protein clumps in the brain — clumps, or aggregates, that are tied to Parkinson’s disease — making this byproduct a potential therapeutic target, a new study in patients…