Scientists at Cognition Therapeutics have found that compounds that are able to dampen the activity of sigma-2 receptors — receptors that are part of a network that controls the destruction of misfolded proteins — are highly effective at preventing molecule trafficking defects driven by the presence of misfolded alpha-synuclein inside…

The levels of a specific RNA molecule that provides instructions to make the alpha-synuclein protein may help, at an early stage, to distinguish patients with Parkinson’s disease from those with dementia with Lewy bodies, a study has found. Researchers said these results highlight the importance of exploring the potential…

Treatment with the antioxidant metal-alloy nanozyme reduced the build-up (aggregation) and transmission of disease-causing alpha-synuclein protein in the nerve cells and brains of a Parkinson’s disease mouse model, a study reported. Investigators believe these findings support further research to evaluate nanozymes as a Parkinson’s treatment.

Researchers have developed a faster method of measuring the rate at which alpha-synuclein protein forms toxic clumps that reliably distinguishes people with Parkinson’s disease from those without the condition. The findings support the use of this test — which cuts by more than half the time required to obtain…

Delivering an alpha-synuclein-targeting molecule, called ASO4, in tiny fatty vesicles reduced toxic alpha-synuclein clumps and dopaminergic neuron loss — two main hallmarks of Parkinson’s disease — and lessened motor impairments in a mouse model of the disease. Results of the study add to previous findings suggesting that these…

Eisai is partnering with Wren Therapeutics to advance the discovery of new small molecule compounds capable of reducing the misfolding and aggregation of alpha-synuclein, the underlying cause of different neurological disorders, including Parkinson’s disease and dementia with Lewy bodies. The research collaboration will leverage Wren’s…

For Alzheimer’s Disease Awareness Month, I would like to share how Parkinson’s and Alzheimer’s have given a daughter and a father a special bond. My dad has Alzheimer’s and I have young-onset Parkinson’s. My mom, or as I call her, Wonder Woman, calls me “the dad whisperer.” But I see…

The U.S. National Institutes of Health (NIH) has given a Small Business Innovation Research (SBIR) grant totaling $2.4 million to Cutaneous NeuroDiagnostics (CND) to advance development of its Syn-One Test for diagnosing Parkinson’s and other neurodegenerative diseases. The SBIR grant (R44NS117214), which…

A new compound called CLR01, which works like a “molecular tweezer” to clear toxic protein clumps that accumulate in brain cells, could become a promising therapy to slow Parkinson’s disease progression, a study suggests. The study, “CLR01 protects dopaminergic neurons in vitro and in mouse models of Parkinson’s…

Seelos Therapeutics has signed an agreement with Duke University in North Carolina to conduct a pre-clinical study of SLS-004, one of its gene therapy candidates, as a treatment for Parkinson’s disease. The proof-of-concept study will seek to determine if the investigational therapy can prevent or delay Parkinson’s disease…