Seal Rock Therapeutics has joined a Michael J. Fox Foundation (MJFF) initiative to develop therapies targeted at the LRRK2 gene for the treatment of Parkinson’s disease. The program, LRRK2 Investigative Therapeutics Exchange (LITE), brings together academic and industry collaborators to support preclinical and clinical development aimed…
The Parkinson’s Foundation has announced that it will provide more than $4.3 million toward 44 research grants that seek to advance understanding of Parkinson’s disease and support efforts toward a cure. “The Parkinson’s Foundation is excited to support these brilliant scientists and see how they are approaching Parkinson’s…
Most people with Parkinson’s disease who’d experienced recurring falls found a personalized, home-based fall prevention program in Australia helpful for improving their safety and confidence. That’s according to a new assessment of the six-month program, dubbed Integrate, which was shown to reduce fall rates by nearly half among participants…
Continuous exposure to low-oxygen air halted neurodegeneration and eased or reversed motor symptoms in a mouse model of Parkinson’s disease, a study reports. “The results raise the possibility of an entirely new paradigm for addressing Parkinson’s,” Fumito Ichinose, MD, PhD, senior coauthor of the study, said in a…
ENERGI-F705PD, a potential disease-modifying therapy for Parkinson’s disease, was found to be safe and well tolerated in a Phase 1 clinical trial involving healthy volunteers, according to developer Energenesis Biomedical. Unlike currently available treatments, ENERGI-F705PD aims to address the causes of Parkinson’s and not just its symptoms.
Lysoway Therapeutics has received a $2.93-million grant from The Michael J. Fox Foundation for Parkinson’s Research (MJFF). The funding will advance a potential new therapy that targets the TRPML1 protein, a promising approach designed to modify the disease’s progression rather than just treating symptoms. “This funding underscores growing…
People with Parkinson’s disease who live in disadvantaged communities tend to have more severe motor symptoms and greater motor disability, according to a study that shows that social and environmental factors, many of which may be modifiable, can influence the severity of the disease. “If environmental exposures or other…
Using mathematical models, researchers at the University of California, San Francisco (UCSF) successfully predicted how to adjust deep brain stimulation (DBS) settings to improve gait for people with Parkinson’s disease, according to a study. With these techniques, researchers could improve DBS and other neuromodulatory therapies that influence nerve…
When combined with deep brain stimulation (DBS), a dynamic, cycling-based exercise program for people with Parkinson’s disease produces changes in brain activity indicative of potential neural rewiring, according to a study. The research was conducted at University Hospitals in Cleveland and the Veterans Affairs Northeast Ohio Healthcare System,…
Infection with a common and otherwise harmless virus called human pegivirus (HPgV) might play a hidden role in Parkinson’s disease, particularly for those with specific genetic risks, according to a new study. “For a virus that was thought to be harmless, these findings suggest it may have important effects,…
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