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Is anyone out there taking methylene blue?
I am interested in hearing about any results.
https://pubmed.ncbi.nlm.nih.gov/28694175/
https://www.sciencedaily.com/releases/2008/08/080818101335.htm
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9 Replies
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I recently became aware of Methylene Blue, and at first was very excited about its potential benefits for Parkinson’s Disease patients. But I read a precaution against taking it if also taking carbidopa/levodopa. I would appreciate more information.
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What is methylene blue
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This may be worth investigating more. But this study was published in 2008. Why have we not heard more about it since then? That raises some serious red flags for me.
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There are recent articles (not just the one below), but I’m not finding studies related to PD. Likely there’s no money to be made, particularly if it’s neuro-restorative in any way.
https://www.onedaymd.com/2022/04/methylene-blue-benefits-dosage-and-side.html?m=1
Some take-always: • Small doses are good, large doses bad. • Get the pharmaceutical grade, not the other kinds. • There are contraindications. Read them, especially if you have Parkinson’s Disease and take medication for it!Do extensive research so you know more about it than your doctor before discussing it. Your doctor will probably say “no” regardless, since it’s not a standard PD medication. How do we break free from that stranglehold?
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Stuart, I would love to read what you maybe tried to post. Somehow it didn’t make it through. Try again?
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At first I thought you were asking about taking blue crystal meth. Having watched all the episodes of the “Breaking Bad” series, I was shocked by your suggestion! But then I looked closer … whew! I decided to check out “methylene blue,” and found a few entries for the drug. None of the sites had much to offer regarding the drug itself and its uses. In some cases the descriptions focused mostly other drugs that should not be taken with methylene blue. I’m actually tempted to say there was a cryptic element to the statements I did find. It’s a mystery to me!
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Based on information recent research (writing this 12/3/25), NOT using information from wikipedia (significant issues with accuracy, and is only as up-to-date as people choose to enter new information), it HAS been showing promise.
For approximately 10 years or more I’d noticed symptoms of “pill rolling” and “vivid” scary dreams, causing him to fight in his sleep, and even fall out of bed, which I was thoroughly tired of because it interrupted MY sleep. I was acutely atuned to symptoms because my father had it. He didn’t want to even consider it, of course, but I did tell his doctor about it, but wasn’t taken seriously.
She finally recently referred him to a neurologist after he started noticing things he couldn’t deny: L arm not swinging like the R one when he walks, shuffling with his left foot, and significant weakness in his L hand not associated with anything else, and when he took off his glasses and held it in his L hand it would tend to shake. ¯\(°_o)/¯ He has no evidence of strokes.
Diagnosis: 7/7/25
First visit: 9/15/25 – Dr. Gilson wanted to start him on the usual stuff. I’d heard of methylene blue and said we’d like to try that first. In one week he started with NeoMethis (each capsule: MB 12 mg, Vitamin C ester 12 mg, cacao powder 235 mg), 1 a day.
In 3 DAYS he noticed improvement! 😮 Said he was starting to smell things again, after about 5 years of being unable to smell ANYTHING (☉｡☉)! He says it’s like his brain is waking up and reconnecting, remembering how to smell again. Improvement is a process, not all at once, more like healing. Don’t know if he’s at 50% or not yet, but he’s starting to smell sulfur-based smells again. Other new smells come in weakly, then continue to improve.
At day 3 he said he wakes up feeling less tired, ready to go, his mind clearer, able to focus better.
He’s walking better with much less less shuffling and more normal walking, but still hasn’t got the arm swing back. But he says by late in the afternoon he starts to feel tired again.
The shaking of his L hand when he holds his glasses is also improving!
I encouraged him to take a dose at lunch, but he says he’s usually not hungry yet, and I haven’t been able to convince him to take it without food.
About 2 weeks later he was up to 1 in the morning and 1 at dinner.
After a few weeks he switched to Nutricel, “Blue Review” (each capsule: MB 7 mg, glycine 86 mg, N-acetyl-L-cysteine 86 mg, creatine monohydrate 86 mg, hydrolyzed collagen – bovine type I and III – 258 mg). He started with one, then in about a week switched to 2 every morning (to be at least to be at least as much MB as a single capsule of the other).
He still takes 1 NeoMethis in the evening (to use them up). He says says Nutricel works better.
Since about 2 weeks ago he is now sleeping better! He hadn’t had the fight or flight dreams, or fallen out of bed since he began MB, but this new improvement was noticeable. The only time he has something remotely like them is if he takes Vivarin or even half a shot of 5-Hour energy during the day. I think he’s genetically very sensitive to high doses of caffeine.
His dad and his brother have the same “fighting in their sleep” symptoms, but they’re in another state and no one has ever even considered screening them for Parkinson’s. I’ve hinted at it, but they tend to treat doctors like they’re the only ones who might have helpful information. We don’t live close enough, so there’s no point in pushing it.
Has an appointment Friday 12/12/25. Don’t know if new dose will have any noticeable difference by then, if at all.
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By the way, an addition to my reply:
We carefully evaluated meds he’s taking to make sure they don’t negatively interact with Methylene Blue – thankfully no problem there. But we took every OTC med we have that could interact with it, and put it in a big Ziploc bag saying “never with methylene blue.” Have also evaluated all supplements.
This has been so successful for him that we will risk nothing.
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