MattR
Forum Replies Created
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My understanding is that currently MRgFUS is not performed bilaterally, so mitigation of tremors on both sides of the body are not supported. I asked my doctor about it and he strongly preferred Deep Brain Stimulus which can treat bilateral tremors and which neurologists have more years of experience with…
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I am interested in almost all research on Parkinson’s. Probably the most important to me, though, are the following two: Ambroxol and High Intensity Interval Training (HIIT).
Ambroxol, the active ingredient in an over-the-counter expectorant, appears to have an ability to improve the action of the lysosomal system (kind of a take out the trash, ie. alpha synuclean, system) of neurons. From my understanding, researchers appear to believe that Ambroxol in doses of approximately 1.2g/day may slow the progression of PD. In the case of HIIT, some recent trials appear to show stronger evidence that HIIT especially, but all exercise generally, may also slow the progression of PD. -
Toni: I am sorry to hear about your struggles. I also have a lot of anxiety and have been working with both my counselor and my neurologist to deal with it. My counselor said that exercise helps and is used for people who do not want to take anxiety medications. My neurologist gave me a prescription for Lexapro, which as I understand it, replaces serotonin which may help with anxiety and depression. However, the side effects of Lexapro are quite scary, so I am trying exercise right now. I would be interested to hear about anyone else’s experience with Lexapro.
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Sabine:
Thank you so much for sharing you husband’s experience with using multiple programs. I am wondering if you would mind commenting on which DBS manufacturer your husband selected. As noted elsewhere there are currently three available, but I am not sure if all manufacturer’s support and allow patients to switch from one program to another.
best regards, -
Sorry, two comments/editorial fixes required:
1. Your spelling of Ambroxol was incorrect, which is why I put an asterisk by my first use … not trying to be picky, just thought you might have troubles doing google searches if spelling is off.
2. Regarding following sentence: “It is sold in tablet form with 20 tablets containing 30mg of Ambroxol dosage per box.”, I think some might be confused. I should have said that each box contains 20 tablets, with each tablet containing 30mg of Ambroxol. Sorry for my poor sentence structure… 🙂 -
Laini Weitz:
Wow, you are doing great with the HIIT! Keep it up!
Regarding your question about Ambroxol* availability in the USA, you are correct that it is not available in the US. However, if you live close to to US southern boarder, you can get it in Mexico where it is given the trade name of “Oxolvan”. It is sold in tablet form with 20 tablets containing 30mg of Ambroxol dosage per box. Note that this means that in order to reach the target of 1.2grams per day, you will need to take about 40 pills per day. In Mexico, the cost for a box of Oxolvan is ~$1.00~1.50. In other countries (like Germany) the dosage is higher (70mg per pill) but the cost is also substantially higher (maybe 10 euros per box).
You commented that you are taking NAC. Can you cite any trials supporting the use of NAC with Parkinsons? I am always interested keeping up with the latest disease modifying medications, as long as there is trial data or serious research papers that back it up.
best regards, MattR