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<p class=”p1″><span class=”s1″> I have seen a lot of research and got a few articles on depression and Parkinsons , but anxiety seems less well covered. I am interested in others who have mood swings that fluctuate with their medication cycle. I have reached the ripe old age of 75 and I had never had a problem with depression or anxiety until June 14, 2023 3 AM. I woke up with the urge to empty my bladder, and a burning sensation that rose up my trunk into my face. This was followed by a feeling like I was being given intravenous epinephrine, and it was coming out of all my fingers like lightning. I was terrified. It lasted about two hours. I told my neurologist that morning when I went for DBS programming. These episodes continued, initially with every medicine cycle, usually at the point on my level, levodopa carbidopa level would be at its lowest. They were relieved by increasing my dose of levodopa carbidopa. We increased it to the point where am I mail order pharmacy would no longer fill the prescription. I used mantras, music, intense exercise, as well as cognitive behavioral therapy to try and keep these attacks at bay. We tried turning the DBS off, but that made no difference, except I got all my dyskinesia back. My doctor started me on an SSRI. The attacks became less intense, but still unpredictable, and still some very severe ones. I find just the anticipation of them frightening. Next month I will see a neuropsychiatrist to to see what he advises. </span></p>