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Selegeline, have you used it?
In John Pepper’s book, Reversing Parkinson’s Disease, he thinks Selegeline (brand name Eldepryl) may have helped him. Have you tried this drug? Side effects? Did it help you?
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8 Replies
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I do use Selegeline (brand name Jumex) from the earliest stage of my PD, two years ago, and still use it It has given me no trouble and I think it arrested the speed of development of the disease.
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manuel, that sounds promising. do you think it helped any of your symptoms?
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I have been on it for about 6 months, which was about 2 months after diagnosis. I do need a lot less sleep then I used to, and have enough energy to do some serious exercise for several hours each day. I think it also helps keep me on a lower dopamine dose. That said, I often have some serious insomnia; not sure whether this drug contributes to it or not. It is taken 2x per day, first thing in AM and then before noon. I believe one of its metabolites is actually methamphetamine, which could explain the insomnia..then again maybe not, I don’t know. The drug also comes with a lot of “black box” warnings about drug and other interactions, many of which I believe are not valid and are remnants from the older group of non-selective MAO inhibitors. Hope that helps.
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andrew, thanks for sharing. thus far, i am hearing more positives about selegeline than negatives. i need to talk to my neuro about it. right now he is thinking of adding zoloft as i do have lack of motivation, apathy and depression.
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Dear Jean, I think selegeline did work for me, As Andrew, I also was prescribed selegeline at the onset of my PD with a low dose of one 10 mg pill a day, taken at 8:00 o’clock every morning. No side effects and slightly less trembling of my hands. With time, after a year, the symptoms returned and selegeline beneficial effects might have slightly worn off or the speed of the normal progress of PD was faster and higher that the positive effects of selegeline. I am still taking it with the same dose and I have the impression that dropping Sinemet has resulted in an improvement in my condition as I now have returned to the level of physical activity I had when my symptoms started. As I wrote earlier, my impression is that my daily fasting routine is helping.
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manuel, interesting that you say “dropping Sinemet has resulted in an improvement in my condition ” . sinemet is considered the gold standard for treating pd but, i dont trust it. 🙁
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Yes Jean, I did say that but in connection with my particular condition of low blood pressure. Sinemet might have had a positive effect on my PD but its lowering further my BP left me practically invalid. No wonder that dropping Sinemet in my condition greatly improved my overall conditions and I feel better than when taking that medicine.
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one of my fellow boxers who has PD also has very low blood pressure to begin with had to reduce his meds. He was getting to a point where he would get so weak and dizzy, he had to sit down with assistance. I dont like drugs!!!
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