[LARRY GLASS]

Very kind of you to provide those links!

[LARRY GLASS]

The adenosylcobalamin (dibencozide b12) study was published in Cell Research (2019): “Vitamin B12 Modulates Parkinson’s Disease LRRK2 Kinase Activity Through Allosteric Regulation and Confers Neuroprotection.”  The best explanatory article about the study that I have read  was published in The Science of Parkinson’s (3/22/19):  “AdoCbl + LRRK2 = modulation.”  You might want to check the literature on methylcobalamin, omega 3 fatty acid vs. omega 6 fatty acid, and Magtein (magnesium L-threonate), with regard to Parkinson’s and otherwise.  Good luck!

[LARRY GLASS]

I cut the pills in half with a pill cutter from CVS.  Incidentally, the serving info on each of the B12 bottles says that 3000 mcg is 125,000% of the recommended “daily value.”  The dosage amounts and intake variations and schedule kind of evolved.  Taking the B12’s sublingually gets the B12 directly into the blood circulation, avoiding the digestive tract, microbiome, and other perils.  On the other hand, swallowing the rest of the B12’s may have a beneficial impact on the microbiome, which can be manipulated. I thought I would try to have it both ways.

If I were you, starting from scratch, I would begin with the dibencozide–like I did–to address the Parkinson’s-related LRRK2-G2019S  neurotoxic protein.  See what results you get.  Then, later on, work in the other B12.  I should add that when I started the Methyl B12, I experienced the same kind of nightmares I had initially had with the dibencozide, with about the same duration and outcome.  I suspect that the nightmares evidence the cleaning out of some really bad stuff and/or putting the brakes on a toxic process.

[LARRY GLASS]

I use Country Life brand, Methyl B12 3000 mcg lozenges (1/2 totally dissolved sublingual, and 1/2 swallowed before breakfast) and Active B12 Dibencozide 3000 mcg lozenges (1/2 totally dissolved sublingual before dinner, and 1/2 totally dissolved sublingual before bedtime with 1/2 swallowed).

[LARRY GLASS]

What I just said about cane sugar might be confusing.  To clarify, I became super-sensitive to cane sugar as a result of taking dibencozide B12.

[LARRY GLASS]

I was diagnosed with Parkinson’s in 2013.  In about April, 2019, on Parkinson’s News Today I saw a summary of a study dealing with my LRRK2-G2019S mutation.  The study basically reported experiments on worms, flied and mice that  were genetically engineered to have that specific mutation.  The researchers found that administration of the adenosylcobalamin version of vitamin B12 (a/k/a dibenconzide) shut down this mutation.  I got the study and read more about it.  I found and began taking this version of B12 in lozenge form (since injections seemed impractical), with immediate and totally unexpected positive results–so that none could be a placebo effect.  My sleep returned to normal, and I discontinued the Klonopin I had been prescribed for sleep.  (One word of warning: during the first week I had nightmarish, horrific dreams.  Since then, I dream more frequently, and dreams are tame.)  A second benefit was a virtual end to constipation.  Another surprise was that my weight dropped from about 172-175  to 160-163–a new normal.  I had become hypersensitive to cane sugar, so that my whole head felt unbearably sweet just tasting it.  This aversion gradually subsided, but not completely.

Subsequently, in October, 2019, in the hopes of helping me recover in other ways, I got it in my head to start taking the methylcobalamin version of of B12, because it has so many positive neurological  benefits.  And in January, 2020, I added fish oil/omega-3 fatty acid based on additional research.  In addition, I take Magtein (a form of magnesium that crosses the blood-brain barrier) to the mix.

I feel I have made these additional gains: I no longer feel brittle psychologically; my thought-speech coordination has improved; I now walk with a normal gait and arm swing, without my left hand tightening into a grip, no longer being self-conscious in this regard; my dexterity is good; and my balance is good.  My carbidopa/levodopa prescription (25-100, 2 tablets by mouth, 3 times a day) has not changed.

Hope this is helpful to someone.

[LARRY GLASS]

I read your note with great interest.  I have been experimenting successfully with the two active B-12 vitamins you mention.  I summarized this in a letter to my neurologist at the beginning of May, that I would provide you, if I only understood how to attach it to this response.  Is there a way to do that?