Parkinson’s News Forums Forums Using Our Forums How are Lewy bodies and mitochondria related?

  • How are Lewy bodies and mitochondria related?

    Posted by DonFiresmith on March 17, 2024 at 12:58 pm

    Does anyone know the connection between clumping of misfolded alpha-synnuclien (Lewy bodies) and mitochondria? I see articles about one or the other, but nothing connecting the two.

    leroy-cornell replied 3 weeks, 5 days ago 3 Members · 3 Replies
  • 3 Replies
  • mark

    Member
    March 19, 2024 at 4:32 pm

    see: Mitochondria-targeted antioxidants for treatment of Parkinson’s Disease…, Jin H, Kanthasamy A et al, Biochimica et Biophysica Acta 1842, (2014), 1282-1294

  • mark

    Member
    March 19, 2024 at 5:24 pm

    Even better: “Alpha synuclein: Pathology, mitochondrial dysfunction and neuroinflammation in PD”, Rocha et al, Neurobiol Dis, 2018 Jan;109

  • leroy-cornell

    Member
    March 19, 2024 at 7:27 pm

    I’ve speculated that exercise, which creates mitochondria, is a way to delay the onset of PD. I’ve also read of a connection between Vitamin B1 and enhancement of mitochondrial functioning. Both exercise & B1 seem to have an affect on PD progression.

Log in to reply.