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    • #15497
      Jean Mellano
      Keymaster

      Since Merck pulled Sinemet, I have had to go on generic carbidopa/levodopa.   I feel much worse, even though I have tried 3 generic brands.  I now experience mild dyskinesia which I did not have on Sinemet.  Have you had bad experiences using generic?  If so, how did you address the issue? Which generic?

    • #15924
      Philippe Joly
      Participant

      I have occasionally been given generic Sinemet and I found it to be 25 to 30% less effective (based on an overall guess, not a scientific assessment). Since then, I have always insisted on being given the brand product. And this was before the new Sinemet.

      • #15932
        Jean Mellano
        Keymaster

        my experience with generic as well.  you can still get the 25×100 brand sinemet where you live?

    • #15965
      Gail Dons
      Participant

      My problem with the brand Sinemet was that it got crumbly in heat, and since I spend several months a year in very hot, un-air conditioned climates, it was especially difficult when I had to cut a tablet in half. The generic actually worked better for me there!

      • #15977
        Jean Mellano
        Keymaster

        I did notice the crumbliness of sinemet when I cut the tabs in half so I got a more expensive cutter with a sharper blade lol.

    • #16035
      Michael R. Scott
      Participant

      When and why did Sinemet 25/100 get pulled of the market? I ordered a replacement of my 25/100 about 45 days ago and with the first pill, I noticed that the pill’s effectiveness fell from roughly 6 hours to 3 hours!…..  And despite that, the price was the same!… 🙁

    • #16062
      Jim Shotton
      Participant

      My Neurologist switched me to Prolopa  and it appears to work well, without the on/off issues that I had. Propola is a Levodopa/Benserazide combo, more popular in Europe.

      Gie it a try

       

      • #16070
        Jean Mellano
        Keymaster

        jim, thanks for sharing that.  it is not available in the USA, but I plan to ask my neuro about it.  The generic C/L dont seem to work for me.

        • This reply was modified 1 month, 1 week ago by Jean Mellano.
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