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Since following Dr Costantini’s(he is an Italian neurologist who began studying a therapeutic protocol to treat symptoms in neurodegenerative diseases)protocol for B1 therapy I have improved considerably. I started taking 2-500mg of B1 per day for a week working up to 4000mg per day, which was the best dose for me. I open 5-500mg capsules and pour them into applesauce and 3 go into my green drink at noon. It has worked incredibly for me.