[Rajan]

I have had Parkinson’s symptoms since 2013 and diagnosed as Parkinson’s since 2017.

I am on medication with Syndopa 275, 1/4 tablet, 3 times a day and Artane 2mg 01 tablet morning and evening. A side effect I experience as follows. With above dosage I just manage dexterity in my arms. But I feel it is not sufficient. For the first two hours since taking medicine, my arms, fingers move faster when typing etc, then 2nd hour till 1.5 hours I feel muscle tightness and lack of dexterity in upper arm and shoulder, most prominently in left arm. The painful feeling in muscles is somewhat as when you do exercise after a long gap. After about 3.5 hours, this feeling diminish slowly.

When I change the dosage of Syndopa 275 to 1/2 tablet, 3 times a day and Artane 2mg with same dose of 01 tablet morning and evening, I feel much better in dexterity in arms (fingers move rapidly across typing keyboard and can move the tooth brush across teeth with control and rapidly). With this dose the muscle tightness starts from about 3rd hour and lasts for about 1.5 hrs.

I have tried various combinations of above dosages, but with maximum dosage  of Syndopa 275 to 1/2 tablet, 3 times a day and Artane 2mg 01 tablet morning and evening. However I am unable to find a dosage that would avoid the muscle tightness in arms.

I have tried even only with Syndopa 275 or only with Artane 2mg to determine which medicine cause the muscle tightness and found with both medicines it causes the muscle tightness and lack of dexterity.

I would like to know if anybody feels as above and managed to avoid the muscle tightness and lack of dexterity that comes after taking medicine.