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  • I was prescribed Nourianz (istradefylline) 20 mg a few months ago. I use it sparingly, only about one or two days per week, as needed for severe “off” episodes that do not respond to the highest doses of levodopa I can take without causing dyskinesia. I do not use Nourianz every day, as prescribed, because:
    1) Nourianz seems to exacerbate my…[Read more]

  • David posted an update 1 month, 3 weeks ago

    When using mannitol for medical purposes, it is given intravenously. When consumed orally, as a dietary sweetener or laxative, mannitol is poorly absorbed by the gut. Oral mannitol is being tested for benefits in Parkinson disease on ClinicalTrials.gov. It seems unlikely for oral mannitol to reach high enough blood levels to reach the brain.…[Read more]

  • Ongentys (opicapone) was recently approved by the FDA as an oral,add-on daily treatment for Parkinson’s patients experiencing off periods while on levodopa. Ongentys increases the amount of levodopa reaching the brain by blocking an enzyme called catechol-o-methyltransferase (COMT),that breaks down levodopa in the blood.  Ongentys was found to be…[Read more]

  • David posted an update 6 months, 2 weeks ago

    My comment concerns the article titled “Different Patient, Different Treatment: Precision Medicine Advances for Parkinson’s Disease”, which states:

    “Sorting patients based upon differences in cellular function (“mechanistic disease stratification” in the words of the authors) may allow treatments to be better targeted to each patient’s unique…[Read more]

  • I have taken rasagiline (Azilect or its generic form) for over a decade, without any problems.  The price dropped when it went generic, and should drop further when manufacturers other than Teva (the original patent-holder) become available.  I do not notice any strong effect from stopping or resuming rasagiline, but I stick with it because the c…[Read more]

  • David became a registered member 7 months, 3 weeks ago

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