[Bolt Upright]

Now, this is an interesting study on Zeolite. As far as heavy metal detox, powdered Zeolite Clinoptilolite seems to be the best. Zeolite: Investigation of the Effectiveness and Safety as an Oral Chelating for Heavy Metals. A comparison between different commercially available preparations https://www.kmizeolite.com/wp-content/uploads/2016/12/Zeolite-and-Human-Detoxification.pdf

[Bolt Upright]

Niacin and Butyrate: Nutraceuticals Targeting Dysbiosis and Intestinal Permeability in Parkinson’s Disease

by Tennekoon B. Karunaratne, Chijioke Okereke, Marissa Seamon, Sharad Purohit, Chandramohan Wakade and Amol Sharma

mdpi.com/2072-6643/13/1/28/htm

Abstract

Dysbiosis is implicated by many studies in the pathogenesis of Parkinson’s disease (PD). Advances in sequencing technology and computing have resulted in confounding data regarding pathogenic bacterial profiles in conditions such as PD. Changes in the microbiome with reductions in short-chain fatty acid (SCFA)-producing bacteria and increases in endotoxin-producing bacteria likely contribute to the pathogenesis of PD. GPR109A, a G-protein coupled receptor found on the surface of the intestinal epithelium and immune cells, plays a key role in controlling intestinal permeability and the inflammatory cascade. The absence of GPR109A receptors is associated with decreased concentration of tight junction proteins, leading to increased intestinal permeability and susceptibility to inflammation. In inflammatory states, butyrate acts via GPR109A to increase concentrations of tight junction proteins and improve intestinal permeability. Niacin deficiency is exacerbated in PD by dopaminergic medications. Niacin supplementation has been shown to shift macrophage polarization from pro-inflammatory to an anti-inflammatory profile. Niacin and butyrate, promising nutrients and unique ligands for the G protein-coupled receptor GPR109A, are reviewed in this paper in detail.

[Bolt Upright]

Niacin and Butyrate: Nutraceuticals Targeting Dysbiosis and Intestinal Permeability in Parkinson’s Disease

by Tennekoon B. Karunaratne, Chijioke Okereke, Marissa Seamon, Sharad Purohit, Chandramohan Wakade and Amol Sharma

mdpi.com/2072-6643/13/1/28/htm

Abstract

Dysbiosis is implicated by many studies in the pathogenesis of Parkinson’s disease (PD). Advances in sequencing technology and computing have resulted in confounding data regarding pathogenic bacterial profiles in conditions such as PD. Changes in the microbiome with reductions in short-chain fatty acid (SCFA)-producing bacteria and increases in endotoxin-producing bacteria likely contribute to the pathogenesis of PD. GPR109A, a G-protein coupled receptor found on the surface of the intestinal epithelium and immune cells, plays a key role in controlling intestinal permeability and the inflammatory cascade. The absence of GPR109A receptors is associated with decreased concentration of tight junction proteins, leading to increased intestinal permeability and susceptibility to inflammation. In inflammatory states, butyrate acts via GPR109A to increase concentrations of tight junction proteins and improve intestinal permeability. Niacin deficiency is exacerbated in PD by dopaminergic medications. Niacin supplementation has been shown to shift macrophage polarization from pro-inflammatory to an anti-inflammatory profile. Niacin and butyrate, promising nutrients and unique ligands for the G protein-coupled receptor GPR109A, are reviewed in this paper in detail.

[Bolt Upright]

Here are some trials!

https://www.google.com/url?sa=t&rct=j&q=&esrc=s&source=web&cd=&ved=2ahUKEwjThay64OPxAhUCK80KHWR_BNIQFnoECCUQAA&url=https%3A%2F%2Fwww.symproveforprofessionals.com%2F%3Fsmd_process_download%3D1%26download_id%3D4347&usg=AOvVaw2wWo0g4cPEmYi9SJXleWwl

[Bolt Upright]

This looks very exciting John! Cuold you please share the studies?

[Bolt Upright]

Here is a farnesol story everybody can read: https://neurosciencenews.com/farnesol-parkinsons-19007/

[Bolt Upright]

I saw a video with the godfather of FMT, Dr Borody, and he mentions one weakness with the modern trial method is they only test one drug at a time. If it does not work they move on. But it takes 3 drugs working together to treat AIDS. This resonated with me.
I like to just keep adding things that make sense to me. As long as I have an idea of what I THINK they are doing and how they compliment each other. Then my plan is to remove them one at a time (instead of adding one at a time).
In fact, I just removed my NAC and Glycine about a week ago and had another RBD episode 2 days ago. So maybe the NAC/Glycine was working for me? I had gone a month without an episode.
Anyway, that is my logic. I know I need to calm my body (B3, Mannitol), okay, it occurs to me I don’t exactly know what I think the rest of the supplements I take are doing. I need to write that part down.
More to come once I review my list.

[Bolt Upright]

Well written Reuben.Everybody is different and to tell you the truth I have spent the last few months looking for one good example of somebody who recovered from PD and have still not found that person.  I have found scientific reports of a couple of people that just seemed to recover on their own, but no names.

And I want to be clear: I am not a smart man. I did not go to college and have no medical training.

I have not been diagnosed with PD. I have been diagnosed with REM Sleep Behavior Disorder, which most doctors consider prodromal PD.  I am working, God willing, to avoid that.

I do feel good about the B3 study from Auburn I linked to above, but take any advice from me with a grain of salt.

I do think there is hope.  Here is one new exciting development: Caloric vestibular stimulation for the management of motor and non-motor symptoms in Parkinson’s disease
https://healthunlocked.com/cure-parkinsons/posts/146496859/caloric-vestibular-stimulation-for-the-management-of-motor-and-non-motor-symptoms-in-parkinsons-disease

[Bolt Upright]

Thank you for asking Todd!  I should preface that I did not go to college but I am a very motivated learner.

My diet is a combination of the Wahls Paleo Plus Protocol and the Specific Carbohydrate Diet. I avoid all foods that are prohibited on either list.  And I avoid dairy even if it is approved. Here is a great resource for SCD: http://www.breakingtheviciouscycle.info/

There are 2 reasons SCD appeals to me:

1. There is some thought that bad bacteria is sitting in our gut getting fed by hard to digest food just sitting around.  SCD is based on only eating food where the molecules are easily digested, so food does not just sit around and ferment.
2. It seems the goal of FMT for PK would be to normalize the gut flora.  I found a study that showed the SCD could normalize gut flora on its own, as long as you still had some of the needed flora: https://pubmed.ncbi.nlm.nih.gov/33291229/

I think I am also usually in ketosis.  I only eat between the hours of 2 PM and 10 PM.

Supplements (everybody please remember I am diagnosed with REMSBD not PD):

I just today cut out a bunch of supplements.  These are what I removed (I may add things back. I was taking too many):

1. Idebenone (is being trialed to slow progression of REMSBD to PD/LBD).
2. Lion’s Mane.
3. NAC.
4. Glycen.
5. Magnesium L-Threonate.
6. Amazon brand Solimo probiotics.

Here is what I kept:

1. B1 500 mg in the morning.
2. Jigsaw Health Butyrex from T.E. Neesby 6 per day (2 with my B1, 2 at 2 PM with food, and 2 at 9 PM with food.
3. Curcumin with both meals. Make sure it is 95% curcuminoids.
4. 100 mg of selenium with 750 mg of Inositol because I have Hashimotos and I read a study where they converted a bunch of people with sub-clinical HT to euro-thyroid using about this protocol. I am not sub-clinical but it still seemed worth a shot to lower inflammation. There is a lot of thought people with HT should not take selenium and neither should men over 50.
5. Niacin 250 mg Time Released at night. There is a study of 47 PD patients on this dosage for a year and all of them had some improvement or no worsening of UPDRS scores. Small study and no control group but I take what I can find. Niacin works as an anti-inflammatory in both the brain and the gut. Niacin binds with the GPR109A receptor, which is anti-inflammatory. Butyrate binds with it too, just not as strongly, so I time my butyrate to be used when the niacin is out of my body.
6. And Melatonin 10 mg. It seems to make me sleep like a baby and there is evidence it is neuroprotective.

And tomorrow I add Zeolite Clinoptilolite powder. Supposedly it detoxes you whole body. And it fixes the leaky gut.  And is an antioxidant and anti-inflammatory. And calming. This is not from the moneymaking pages, this is from the NIH: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6515299/

I’m kind of an outlier on the SCD and the Zeolite.  I look at everything and if it makes sense to my high school educated brain I might just give it a whirl.

I also have my Ambroxol but I am still on the fence. And I have a red light that I need to start pointing at my head.  Tomorrow!

Thanks, Bolt.

 

[Bolt Upright]

Why Niacinamide Beth? The recent B3 study used Niacin 250 mg Slow Release.

https://www.researchgate.net/publication/352486597_Niacin_Enhancement_for_Parkinson's_Disease_An_Effectiveness_Trial

[Bolt Upright]

Thank you so much for weighing in Todd Kitten! A microbiologist, that is exactly what we need on this case!

I did send an e-mail to Doctor Jin-Long Zheng asking:

1. The paper shows UPDRS scores went down in month 1 and month 3. Did you continue to collect UPDRS scores for the entire 24 months of the study? If so, did they revert to baseline?
2. Did all the subjects that had the colonoscopy delivered FMT improve scores in all the categories (PSQI, HAMD, HAMA, PDQ-39, NMSQ and UPDRS-III) or did some get worse?
3. The two subjects that reported satisfaction with the treatment for 24 months, do you know if they continued to improve? Do you think their PD progression has been stopped?

No reply yet, but it has not been long.

I am so interested in hearing your opinions on so many things.  I know my gut issues have gone back 40 years and I seem to have been able to normalize them pretty well with the Specific Carbohydrate Diet and Intermittent Fasting. I’m thinking a handful of frozen crapsules a day for 6 months on top of SCD and I might have things back on track.

FYI: I have not been diagnosed with PK. I have been diagnosed with REM Sleep Behavior Disorder which, it seems, a LOT of doctors consider pre-Parkinson’s.

Thank you so much!

[Bolt Upright]

Hello Russ, I am so excited about your results. I am wondering.  Your profile says you were self diagnosed.  Since that self diagnosis, have you been diagnosed by an MD?

Don’t get me wrong, I do think you are onto something.  In fact there is a recent study that came out showing 250 mg of B3 stopped disease progression in 47 out of 47 people in a trial.
Niacin Enhancement for Parkinson’s Disease:
https://www.researchgate.net/publication/352486597_Niacin_Enhancement_for_Parkinson's_Disease_An_Effectiveness_Trial

[Bolt Upright]

Hello Russ! I just started Niacin last week (250 mg Time Released) and started the Butyrate that you recommended yesterday.

How are you doing? Is it still working for you?

Do you take any other supplements?

Thanks,

Bolt