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September 16, 2019September 16, 2019

Michael J. Fox Foundation Funds Search for Parkinson’s Urine Biomarkers

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The Michael J. Fox Foundation for Parkinson’s Research (MJFF) is funding work at Tymora Analytical Operations that screens for protein biomarkers in urine to help detect the neurodegenerative disease earlier. ... Read more

September 13, 2019September 13, 2019

Updated Canadian Guideline Reflects Latest Advances and Adds Palliative Care Section

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Updated recommendations on Parkinson’s disease have been published in the Canadian Guideline for Parkinson Disease, which includes a new section about palliative care. Focused on issues relevant to the ... Read more

September 13, 2019September 13, 2019

Fox Foundation Offers Guide to Help with Parkinson’s Cognitive Symptoms

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The Michael J. Fox Foundation (MJFF) is offering a new guide to help people better understand Parkinson’s cognitive symptoms and ways of dealing with them. The 33-page guide, “Navigating ... Read more

September 12, 2019September 12, 2019

Early Trial for Prevail’s One-time Gene Therapy PR001 to Start Soon

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Prevail Therapeutics will soon start its Phase 1/2 clinical trial evaluating the safety, tolerability, and early efficacy of its one-time gene therapy — called PR001 — for Parkinson’s disease associated ... Read more

September 12, 2019September 12, 2019

Phase 2 Clinical Trial Recruiting People with Early Parkinson’s to Explore Experimental K0706

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Sun Pharma Advanced Research Company (SPARC) is conducting a Phase 2 clinical study to evaluate the safety and effectiveness of its experimental Abl inhibitor K0706 in people with early ... Read more

September 11, 2019September 11, 2019

Lewy Bodies Diverse in Structure and Some Fibrils Can Migrate, Study Reports

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A detailed analysis of the structure of alpha-synuclein clumps suggests that Parkinson’s is a systemic disease, whose characteristic protein aggregates can move about inside the brain and migrate beyond the ... Read more

September 11, 2019September 11, 2019

Urine Levels of Compound Rise Quickly After Brain Injuries Linked to Parkinson’s, Study Finds

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Explosions that cause even mild traumatic brain injury can trigger molecular changes that, later in life, lead to neuroinflammation and degeneration, and a greater risk of Parkinson’s disease. But work ... Read more

September 10, 2019September 10, 2019

Parkinson’s May Originate From Alpha-Synuclein Migrating From the Gut, Rat Study Shows

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New experimental evidence collected from rats shows that alpha-synuclein — the protein that causes Parkinson’s disease — can travel from the intestines to other organs, such as the heart ... Read more

September 10, 2019September 10, 2019

First Parkinson’s Patient Dosed in Early Trial of DNL151, Potential LRRK2 Inhibitor

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A Phase 1b clinical trial exploring the oral LRRK2 inhibitor DNL151 has started dosing Parkinson’s patients, the therapy’s developer Denali Therapeutics announced. The 28-day, multicenter, and double-blind study (NCT04056689) is testing ... Read more

September 9, 2019September 9, 2019

Engineered Protein Binds to Alpha-synuclein to Prevent Toxic Clumping, Study Reports

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An engineered protein known as AS69 is able to bind to individual units of alpha-synuclein to prevent them from clumping, and — in a fly model of Parkinson’s disease — ... Read more

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